“Given Darwinism, even our cognitive faculties must be the result of natural selection. Every aspect of human brain physiology and psychology was entirely fixed by its survival value. This means that nowhere along the human evolutionary path did a concern for truth necessarily come into play. So long as an organism’s cognitive apparatus enables it to stay alive, its beliefs need not be true or even reasonable. There is no necessary connection between the survival potential of a cognitive system and the truth of the beliefs it produces...this means that if naturalism is true, then we have no reason to be confident that any of our beliefs are actually true, and the includes our belief in the truth of naturalism.”
As quoted by James Spiegel in The Making of an Atheist, p. 58-59
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In the skeptics zeal that everything is this great "unknowable" they seem to fail to comprehend that by destroying any certainty of the truthfulness of the christian worldview that their worldview falls victim to their own line of reasoning. While they may think themselves smart for frustrating the line of evidences for the Christian worldview the unbeliever has actually undermined their own mines in the process of arguing against the case for Christianity.
Unbelievers either fall into the category of either being absolutely certain of their total uncertainty or being totally uncertain about their absolute uncertainty. Both positions can't pass their own test of truth and in the process actually destroy meaningful knowledge.
I love it when Ravi Zacharias says that as apologists we must question the questioner. The above is one way to do that.